Phenibut is a well-known nootropic drug of systemic action, referring to psychostimulants with anxiolytic activity.

The main active ingredient is phenibut, also called aminophenyl butyric acid. It is a derivative of natural brain mediators, in particular GABA. GABA is needed by the central nervous system for metabolic processes and to maintain the efficient operation of all brain cells. The lack of this substance leads to various neurological diseases. Phenibut acts as a replacement therapy, restoring the necessary concentration of the mediator.

For the first time, Phenibut was synthesized by V. Perekalin in the center of experimental medicine back in the 1970s, and five years later the tranquilizer became widely used in medicine - they were even equipped with cosmonauts' pharmacy complexes.

Clinical and pharmacological group

Nootropic agent, is a gamma-amino-beta-phenylbutyric acid hydrochloride.

Terms of sale from pharmacies

Can be bought without a doctor's prescription.


How much does Phenibut cost in pharmacies? The average price is at 150 rubles.

Composition and release form

The drug is available in two forms:

  • pills;
  • substance powder.

Phenibut tablets are made in a dosage of 250 mg. The color of the flat cylindrical tablets varies from slightly yellow to white. Each tablet has a risk and chamfer. One blister pack contains 10 pieces.

The substance-powder Phenibut is a less common form of drug release. It is produced in a dosage of 100 mg and is a white powder with a characteristic salty-sour taste. It is well dissolved in water and alcohol.

Pharmacological effect

Phenibut is a nootropic drug, which is a gamma-amino-beta-phenybutyric acid hydrochloride.

The use of Phenibut has a direct effect on GABA receptors, and also has an antiplatelet, tranquilizing, antioxidant and psychostimulating effect.

Phenibut affects cerebral blood circulation, normalizes tissue metabolism, which improves the brain's functional state (increases the linear and volumetric blood flow velocity, reduces the vascular tone of the brain, has antiaggregant effects on the brain, improves microcirculation). According to reviews, Phenibut contributes to the disappearance or maximum reduction of anxiety, fear and anxiety, has an anticonvulsant effect and a positive effect on sleep.

The drug has no effect on adreno- and cholinergic receptors. Reduces the severity and duration of nystagmus, lengthens the latent period. Positively, Phenibut influences psychological indicators (memory, attention, accuracy and speed of sensory-motor reactions). Reduces the manifestations of asthenia, improves mental performance, minimizes vasic-vegetative symptoms (headache, sleep disturbances, emotional lability, irritability, feeling of heaviness in the head).

Course use Phenibut helps to improve mental and physical performance, normalizes sleep and improves memory. According to reviews, Phenibut significantly improves the condition of patients with speech and movement disorders. Patients with asthenia feel improvement from the first days of taking the drug, increased motivation to work. The drug has no stimulating or sedative effect.

With such indications for Phenibut as neurogenic lesions of the stomach and heart, it stabilizes the processes of lipid peroxidation. In elderly patients, it does not cause excessive lethargy, and there is no relaxing after-effect. In the tissues of the eye improves microcirculation, reduces the inhibitory effect of ethanol on the central nervous system.

Indications for use

Phenibut improves the functioning of the brain, nervous system, sleep. Improves performance, attention, memory without getting used to. Indications for use are the following symptoms and diseases:

  • decrease in intellectual abilities;
  • memory disorders;
  • asthenic conditions;
  • Meniere's disease;
  • motion sickness prevention;
  • incontinence or urinary retention in children;
  • stuttering, nervous tics in children;
  • neurosis, feeling of constant anxiety, anxiety;
  • adjuvant treatment of alcoholism (relief of conditions and disorders during alcohol withdrawal);
  • insomnia and frequent nightmares (in the elderly and young people);
  • with causeless fear.

Phenibut for babies and babies

Phenibut is a drug with low toxicity, mild action and minimal risk of side effects, so it can be used for the treatment of neurotic and anxiety disorders in children and the elderly. Quite a long period of time Phenibut is used in the treatment of tics, stuttering, urinary incontinence and neurosis in young children of preschool age. Moreover, the result of the combined use of Phenibut and special techniques or other medicines aimed at correcting the violation is good. Improvement is achieved in all children, and full recovery - in 65 - 95%, depending on the severity of the initial state. Phenibut in children is used in a dosage of 20-100 mg per day for 2-4 weeks. Longer use of the drug is not recommended so that the child does not develop psychological dependence on the pills.

Infants are not recommended to give Phenibut, because this drug can have a multidirectional effect on the child, which is impossible to predict in advance. Therefore, psychiatrists advise to refrain from using Phenibut for at least two years. If the child is hyperactive, mournful, mobile and suffers from other functional behavioral disorders, then other drugs should be used, the effects of which are more predictable and understandable both for the doctor and for the parents of the baby.

The recommended use of Phenibut for children described above in practice is practically not being complied with at the present time due to the peculiarities of diagnostics, perception and differentiation of the norm states and pathologies of the behavior of babies. In the countries of the former USSR, the practice of overdiagnosis of various neurological, mental and behavioral disorders in children, especially younger ones, has developed. This means that in clinics, children are diagnosed with a disease that they do not have, and begin treatment with potent drugs, including Phenibut. And if, with a truly existing disease, Phenibut will be effective and indicated, in the case of overdiagnosis, the drug will not bring the child anything except possible side effects, feelings of inferiority and possible exacerbation of psychological disorders.

Phenibut is most often prescribed for hyperactivity, constant hysteria and neurosis, and the diagnosis is made on the basis of a simple examination of the child and from the words of the mother. That is, there is an exclusively subjective perception of the child’s behavior, which is evaluated from the position of the mother’s and the doctor’s views as “right” or “wrong”. And if the child’s behavior is assessed as improper, then he is given a clinical diagnosis and begins treatment with Phenibut or another nootropic drug, for example, Fenotropil. Meanwhile, such a diagnosis by a neurologist or psychiatrist is unacceptable, since this is a profanation of medical science. Any neurological or psychiatric diagnosis is made only on the basis of objective results of tests, examinations, examinations and conversations with the child, as well as monitoring him in various situations. If during all these examinations the doctor reveals really existing violations, then only in this case can he make an appropriate diagnosis.

If tests and conversations were not conducted, then the child cannot be diagnosed only from the words of the mother, who seems to be crying not so much, screaming a lot, having hysterics, etc. After all, there are no objective data for the presence of the disease, but there are only observations of the mother, which are at odds with the ideas that have formed in her head about how the child should behave and react to various stimuli. When, on the basis of such complaints of the mother, the doctor makes a clinical diagnosis to the child, it is precisely overdiagnosis that takes place. Remember that even mental disorders are strictly classified and there are special tests and methods for their detection that exclude the subjectivity of the doctor’s perception, and not just the mother’s observation of her child’s behavior. Therefore, Phenibut should not be used for young children if there are no violations confirmed by surveys.

In most cases, children do not have severe disorders that are the clinical diagnosis. Usually, the child suffers from a behavioral disorder or mental reactions that are adjusted by the correct behavior of the parent. In such situations, the use of tinctures valerian or motherwort is enough to calm the child. However, to normalize the child's behavior, parents will have to work, changing their behavior and habits, as well as carefully controlling their actions.

Returning to Phenibut, it can be said that the drug is often prescribed for the treatment of non-existent pathologies identified during “overdiagnosis”. However, such use of medication cannot be considered correct and justified; therefore, all recommendations remain on the conscience of the particular doctor and parents of the child.


According to the annotation to the drug, the list of contraindications is as follows:

  • individual intolerance to Phenibut or any of the excipients;
  • lactation period;
  • pregnancy;
  • acute renal failure;
  • age up to 8 years.

In diseases of the digestive system and ulcers of the gastrointestinal tract, the drug is used with caution and in minimal doses.

Appointment during pregnancy and lactation

Phenibut is contraindicated in pregnancy, as well as women who are breastfeeding. Exceptions are cases where the expected benefit to the mother outweighs the potential risks to the baby.

Dosage and method of use

As indicated in the instructions for use, tablets can be used regardless of the meal time. The course of treatment is on average 4-6 weeks, or a special one on the recommendation of your doctor.

The average dose of medication for adults is from 250 to five hundred mg. Phenibut three times a day, a single dose - not more than 750 milligrams. Depending on the type and form of the disease, a specialist dosage may be prescribed.

The drug can be used for children. A single dose of the drug for a child from two to eight years is 150 milligrams, it is recommended to take 50-100 milligrams 3 times a day. For children between eight and fourteen, the maximum single dose is three hundred milligrams, 250 milligrams are recommended three times a day.

Adverse reactions

The side effects of the drug may appear as early as the first day or even hours of use. Sometimes this happens after a long course of treatment. Phenibut is usually well tolerated and side effects are less frequent, but still happen. As a rule, reactions to receiving Phenibut occur at the beginning of treatment.

The following side effects on taking the drug are noted:

  • allergic manifestations in the form of red spots, rash, skin itching
  • drowsiness
  • nausea
  • headache
  • excitation
  • dizziness


An overdose of the drug is accompanied by the following symptoms:

  • increased drowsiness;
  • lower blood pressure;
  • nausea;
  • vomiting;
  • development of renal failure.

Treatment involves gastric lavage, induction of vomiting and the appointment of symptomatic therapy. The drug has no specific antidote.

Since Phenibut is a low-toxic compound, only prolonged use of it in doses substantially higher than therapeutic (from 7 to 14 g per day) can provoke the development of hepatotoxic effects.

In particular, the patient increases in excess of the physiological norm the number of eosinophils in the peripheral blood, and also steatosis (fatty infiltration) of the liver may develop - a chronic disease caused by the accumulation in the liver tissues of a large amount of triglycerides and characterized by fatty degeneration of the organ cells.

Special instructions

With prolonged use, it is necessary to evaluate the blood and liver.

Phenibut is usually taken in two to three weeks and then repeated after the same amount of time. However, the severity of symptoms and the nature of the disease can cause a lengthening of the course or an increase in a single dose.

Compatibility with other drugs

The drug Phenibut enhances and lengthens the therapeutic effect of drugs from the group of sedatives, tranquilizers, antidepressants, analgesics, anticonvulsants, antipsychotics. Given this information, Phenibut is not recommended to be prescribed simultaneously with the listed groups of drugs or to adjust the dose of the latter.


We offer to read the reviews of people who used Phenibut:

  1. Nice Phenibut took Baltic production in depressive disorder. Has passed two medical courses for a month each. I liked the effect, the mood improves, there is no clouding in the head, as when taking other prescription tranquilizers and antidepressants. The disadvantage is the price, the course needs a lot of packages.
  2. Natalia. I like the drug very much. From time to time I accept, mainly to improve sleep, but it helps only the production of the Baltic states, I tried the production of Moscow and Belarus - useless. Giving to mom, but for some reason she had a headache after taking it.
  3. Peter. I spend on drink Phenibut every autumn. Often by this time there is already apathy to everything, I cannot wake up in the morning, and at night insomnia torments, my head begins to ache. After I take 1 tablet 3 times a day for a whole month, everything passes. I don’t see any difference in domestic or import manufacturers, everything helps.


The pharmaceutical market offers several drugs of similar action.

Among them are Adaptol, Noofen, Afobazol and others. All active ingredients differ in the strength of the therapeutic effect and its features. Phenibut is considered one of the safest drugs. Its price for 10 tablets is approximately 100 rubles. Among the analogues you can find drugs that will be both more expensive and cheaper than Phenibut.

Before buying an analogue, consult your doctor.

Shelf life and storage conditions

Keep the packaging with the drug must be out of the reach of children at room temperature. The shelf life of the tablets is 3 years from the date of manufacture, at the end of this period, the drug is disposed of.

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